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Two case reports of macrovascular complications in fibrocalculous pancreatic diabetes
V Mohan1, A Ramachandran, M Viswanathan
1Diabetes Research Centre, Madras, India.
Abstract:
Fibrocalculous pancreatic diabetes (FCPD) is a form of diabetes secondary to chronic, non-alcoholic pancreatitis in tropical countries. Being a secondary form of diabetes, vascular complications are believed to be rare. In this paper we present two case reports of macrovascular complications (myocardial infarction and gangrene). This shows that large vessel disease does occur in FCPD.
Insights
Fibrocalculous pancreatic diabetes (FCPD), a tropical diabetes form, is unexpectedly linked to macrovascular issues like heart attack and gangrene. This challenges the belief that large vessel disease is rare in FCPD patients.
Area of Science:
- Endocrinology
- Cardiology
- Gastroenterology
Background:
- Fibrocalculous pancreatic diabetes (FCPD) is a secondary diabetes form prevalent in tropical regions, characterized by chronic pancreatitis.
- Vascular complications, particularly macrovascular disease, are generally considered uncommon in FCPD.
Observation:
- This study presents two distinct cases of FCPD patients experiencing significant macrovascular complications.
- The observed complications included myocardial infarction (heart attack) and peripheral gangrene.
Findings:
- The findings demonstrate that macrovascular complications, such as myocardial infarction and gangrene, can occur in individuals with FCPD.
- This suggests that large vessel disease is not as rare in FCPD as previously assumed.
Implications:
- These cases highlight the need to consider and screen for macrovascular disease in FCPD patients.
- Further research is warranted to understand the mechanisms and prevalence of vascular complications in FCPD.