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Thrombocytosis and thrombocythemia: qualitative platelet abnormalities
Nihon Ketsueki Gakkai Zasshi : Journal of Japan Haematological Society
|December 1, 1989
Summary
Primary thrombocythemia, a bone marrow disorder, often presents with abnormal platelet function, leading to bleeding or thrombosis. Secondary thrombocytosis is typically asymptomatic with normal platelet function, highlighting key differences in platelet behavior.
Area of Science:
- Hematology
- Platelet Physiology
Background:
- Thrombocytosis encompasses primary (thrombocythemia) and secondary forms.
- Secondary thrombocytosis is usually asymptomatic with normal platelet function.
- Primary thrombocythemia is frequently linked to bleeding, thrombosis, and platelet abnormalities.
Purpose of the Study:
- To review platelet abnormalities in thrombocythemia.
- To present recent findings on functional and biochemical platelet alterations in thrombocythemia.
Main Methods:
- Review of existing literature on platelet abnormalities.
- Focus on recent studies investigating platelet function in thrombocythemia.
Main Results:
- Identified abnormal platelet aggregation in thrombocythemia.
- Observed deficient epinephrine-induced cytoplasmic Ca2+ elevation and aggregation.
- Found altered platelet responses to thromboxane A2, indicating receptor defects.
- Detected abnormal platelet 12-lipoxygenase enzyme activity.
Conclusions:
- Platelets in thrombocythemia exhibit multiple functional and biochemical defects.
- These qualitative platelet defects may serve as models for understanding platelet pathophysiology.