[The effect of cholinergic agents on the analgesic effect of nonnarcotic analgesics]

The effect of cholinergic agents on the analgetic effect of analgin (pyrazoline derivative) and chemical compounds (quinazoline and triazole derivatives) has been studied in experiments on white mice using a "hot plate" technique. It has been found that an M-cholinomimetic pilocarpine decreases pain sensitivity and enhances considerably the analgetic effect of non-narcotic analgesics, especially that of quinazoline and triazole derivatives. At high doses (10 mg/kg) pilocarpine increases drastically the toxicity of analgin. Contrastingly, an M-cholinoblocker atropine does not affect considerably the pain sensitivity, however blocks completely the analgetic effect of all the drugs studied. The role of cholinergic mechanisms in the maintenance of pain sensitivity level and the onset of the analgetic effect of non-narcotic analgesics as well as the clinical value of the data obtained are discussed.