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Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes
Published on: September 27, 2018
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Mycobacterium abscessus Complex Infections in Humans.
Emerging Infectious Diseases
|August 22, 2015
Summary
Mycobacterium abscessus complex causes serious infections and is resistant to many drugs. Different subspecies require distinct treatments due to genetic variations affecting macrolide resistance.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Mycobacterium abscessus complex (MAC) is a group of rapidly growing, multidrug-resistant nontuberculous mycobacteria.
- MAC infections manifest in various forms, including skin and soft tissue diseases, CNS infections, bacteremia, and ocular infections.
- Outbreaks of MAC are linked to cosmetic procedures and nosocomial transmissions.
Purpose of the Study:
- To highlight the clinical significance of Mycobacterium abscessus complex.
- To differentiate between MAC subspecies and their impact on treatment outcomes.
- To emphasize the urgent need for improved diagnostics and therapeutics.
Main Methods:
- Subtyping of M. abscessus complex based on genetic patterns, specifically the erm(41) gene.
- Review of current antimicrobial treatment strategies for MAC infections.
- Analysis of transmission routes and outbreak dynamics.
Main Results:
- MAC comprises three subspecies: M. abscessus subsp. abscessus, M. abscessus subsp. massiliense, and M. abscessus subsp. bolletii.
- The erm(41) gene patterns differ between M. abscessus subsp. abscessus and M. abscessus subsp. massiliense, influencing macrolide resistance.
- Current first-line treatments include clarithromycin, amikacin, and cefoxitin.
Conclusions:
- Distinct genetic profiles of MAC subspecies necessitate tailored treatment approaches.
- The emergence of multidrug resistance in MAC underscores the need for novel therapeutic agents.
- Enhanced infection control measures are crucial to prevent MAC transmission and outbreaks.
Keywords:
Mycobacterium abscessusMycobacterium abscessus complexMycobacterium bolletiiMycobacterium massiliensebacteriaclinical diseasecosmetic proceduresidentification methodsmultidrug resistantmycobacterianomenclaturenontuberculousnosocomialoutbreakstaxonomytransmissionMore Related Videos
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