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Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
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Nanocarriers in Improved Heparin Delivery: Recent Updates.
Balak Das Kurmi, Pawan Tekchandani, Rishi Paliwal
1SLT Institute of Pharmaceutical Sciences, Guru GhasidasVishwavidyalaya (A Central University), Bilaspur (CG), INDIA. srai2k@gmail.com.
Current Pharmaceutical Design
|August 22, 2015
Summary
Heparin, an anticoagulant, faces delivery challenges due to its parenteral administration. Nanocarriers offer a promising solution for noninvasive heparin delivery, improving bioavailability and therapeutic effectiveness.
Area of Science:
- Pharmacology
- Biotechnology
- Drug Delivery Systems
Background:
- Heparin is a vital anticoagulant for thrombosis and coronary syndromes.
- Its clinical utility is hindered by parenteral administration, despite minimal side effects.
- Heparin also plays roles in inflammation, immune cell migration, and tumor metastasis.
Purpose of the Study:
- To review research on noninvasive heparin delivery methods.
- To explore strategies for overcoming biological barriers for heparin.
- To highlight the role of nanocarriers in improving heparin bioavailability.
Main Methods:
- Review of existing literature on heparin delivery systems.
- Analysis of nanocarrier technologies (liposomes, nanoparticles, dendrimers) for heparin.
- Evaluation of various noninvasive routes (oral, nasal, pulmonary, transdermal).
Main Results:
- Nanocarriers significantly enhance heparin pharmacokinetics and efficacy.
- Various nanocarrier systems show potential for improving heparin bioavailability.
- Overcoming biological barriers is crucial for successful noninvasive heparin delivery.
Conclusions:
- Noninvasive heparin delivery is achievable through advanced nanocarrier systems.
- Nanotechnology offers a viable alternative to parenteral administration for heparin.
- Further research into nanocarrier-based heparin delivery promises improved therapeutic outcomes.
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