Prognostic value of SYNTAX score based on coronary computed tomography angiography

Area of Science:

• Cardiology
• Radiology
• Medical Imaging

Background:

• The prognostic value of computed tomography (CT)-based SYNTAX score for long-term outcomes is unknown.
• Coronary artery disease (CAD) assessment often involves both CT angiography (CCTA) and invasive coronary angiography (ICA).

Purpose of the Study:

• To evaluate the prognostic value of the CT-SYNTAX score in predicting major adverse cardiac events (MACEs).
• To compare the predictive performance of the CT-SYNTAX score against CCTA-derived CAD findings and the ICA-based SYNTAX score.

Main Methods:

• Retrospective analysis of 339 patients with suspected CAD who underwent both CCTA and ICA.
• SYNTAX scores were calculated from both CCTA and ICA data.
• Cox proportional hazard models and time-dependent receiver operating characteristic curve analysis were used to assess MACE prediction.

Main Results:

• Higher CT-SYNTAX score groups (≥33) and ICA-SYNTAX score groups (23-32 and ≥33) were associated with increased MACE risk.
• CT-SYNTAX score showed comparable predictive ability (iAUC) to ICA-SYNTAX score and CAD vessel count on CCTA.

Conclusions:

• CT-SYNTAX score offers a valuable non-invasive tool for predicting MACEs.
• This score is particularly useful for patients with complex coronary artery disease.