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The electroretinogram.

A Harden1, G G Adams, D S Taylor

  • 1Department of Clinical Neurophysiology, Hospital for Sick Children, London.

Archives of Disease in Childhood
|July 1, 1989
PubMed
Summary
This summary is machine-generated.

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Electroretinogram (ERG) testing in children, combined with visual evoked potentials, helps diagnose various conditions. This non-sedated method is reliable for identifying ocular and neurodegenerative disorders.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Genetics

Background:

  • The electroretinogram (ERG) is a diagnostic tool for retinal function.
  • Combining ERG with visual evoked potentials (VEPs) can enhance diagnostic capabilities.
  • Non-invasive methods are crucial for pediatric assessments.

Purpose of the Study:

  • To establish normal electroretinogram parameters in infants and children.
  • To evaluate the utility of ERG, combined with VEPs, in diagnosing pediatric disorders.
  • To assess the feasibility of routine, non-sedated ERG recordings in young patients.

Main Methods:

  • Recorded flash electroretinograms (fERG) using a skin electrode on the nose in 4465 children over 10 years.
  • Combined fERG with flash visual evoked potentials (fVEP).

Related Experiment Videos

  • Defined normal fERG parameters using 240 control patients aged 1 day to 17 years with normal fVEP and no suspected retinal pathology.

    • Main Results:

    • Established age-specific normal electroretinogram parameters.
    • Identified 332 patients with absent or significantly reduced ERG amplitudes.
    • Categorized these patients into ocular disorders (195), neurodegenerative disorders (94), and various syndromes (43).
    • Noted that fundus examination did not always reveal abnormalities in affected patients.

    Conclusions:

    • Non-sedated electroretinogram recordings are feasible and reliable in infants and uncooperative children.
    • ERG, particularly when combined with VEPs and sometimes EEG, aids in diagnosing diverse pediatric conditions.
    • These electrophysiological studies have significant implications for identifying genetic disorders.