Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

54.0K
Overview
54.0K
Vaccines01:21

Vaccines

49
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the...
49
Vaccine Production01:23

Vaccine Production

61
Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
61
Steps in Outbreak Investigation01:18

Steps in Outbreak Investigation

704
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
704
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

4.9K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
4.9K
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

72
PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure...
72

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Indirect Effects in Health Economic Models of Vaccines: Should We Include Them, and How Do We Model Them?

Applied health economics and health policy·2026
Same author

Safety, tolerability, and immunogenicity of an adult-specific pneumococcal conjugate vaccine, V116, in people living with HIV (STRIDE-7): a two-part, parallel-group, randomised, active comparator-controlled, international, phase 3 trial.

The lancet. HIV·2025
Same author

A phase 3 randomized, double-blind clinical study to evaluate the safety and immunogenicity of V116 when administered concomitantly with influenza vaccine in adults 50 years of age or older.

Vaccine·2025
Same author

Lessons learned from successful implementation of tetanus and diphtheria vaccination programs.

Clinical microbiology reviews·2025
Same author

Vaccination Intentions During Pregnancy and Among Parents of Young Children.

JAMA network open·2025
Same author

What is the current evidence base for measles vaccination earlier than 9 months of age?: Report from an informal technical consultation of the World Health Organization.

Vaccine·2025

Related Experiment Video

Updated: Apr 5, 2026

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.7K

Lessons Learned From Making and Implementing Vaccine Recommendations in the U.S.

L Reed Walton1, Walter A Orenstein2, Larry K Pickering3

  • 1National Center for Immunization and Respiratory Tract Diseases, CDC, Atlanta, Georgia.

American Journal of Preventive Medicine
|August 23, 2015
PubMed
Summary

Advisory Committee on Immunization Practices vaccine recommendations face implementation challenges. Unexpected events, including adverse reactions, shortages, hesitancy, public perception, and cost, impact vaccine rollout and public health.

More Related Videos

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
12:09

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

Published on: May 2, 2011

43.5K
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

11.5K

Related Experiment Videos

Last Updated: Apr 5, 2026

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.7K
Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
12:09

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

Published on: May 2, 2011

43.5K
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

11.5K

Area of Science:

  • Public Health
  • Immunization Practices

Background:

  • Vaccine recommendations by the Advisory Committee on Immunization Practices (ACIP) are crucial for public health.
  • Implementation of these recommendations can be complex and face unforeseen challenges.

Purpose of the Study:

  • To examine unexpected events that have occurred during the implementation of ACIP vaccine recommendations.
  • To identify factors influencing the success and challenges of vaccine rollout.

Main Methods:

  • Review of post-publication events related to ACIP vaccine recommendations.
  • Analysis of factors such as adverse events, community protection, vaccine shortages, hesitancy, public perception, and cost.

Main Results:

  • Changes in recommendations have occurred due to adverse events.
  • Community protection has been observed as a benefit of specific vaccination strategies.
  • Vaccine shortages, public hesitancy, perception, and cost have impeded implementation.

Conclusions:

  • The implementation of vaccine recommendations is influenced by a dynamic interplay of factors.
  • Addressing these challenges is essential for effective vaccine program delivery and public health outcomes.