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Related Experiment Video

Updated: Apr 5, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

Donor Unrestricted T Cells: A Shared Human T Cell Response.

Ildiko Van Rhijn¹, D Branch Moody²

¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; and Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, the Netherlands i.vanrhijn@uu.nl.

Journal of Immunology (Baltimore, Md. : 1950)

|August 23, 2015

Summary

Donor restriction, influenced by MHC genes, impacts transplantation and antigen discovery. Donor unrestricted T cells, recognizing CD1 and MR1 molecules, offer new therapeutic avenues outside the MHC system.

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Area of Science:

Immunology
Molecular Biology

Background:

T cell recognition is typically restricted by Major Histocompatibility Complex (MHC) genes, leading to donor-specific responses.
This donor restriction influences organ transplantation and the identification of disease-associated antigens.

Purpose of the Study:

To review emerging evidence on the prevalence and function of donor unrestricted T cells.
To highlight T cell populations that operate independently of the classical MHC system.

Main Methods:

Review of existing scientific literature and experimental data.
Analysis of T cell receptor (TCR) characteristics and target molecule expression (CD1, MR1).

Main Results:

Donor unrestricted T cells recognize conserved molecules like CD1 and MR1, present across human populations.
These cells often express invariant TCRs with broad species distribution.
Natural Killer T (NKT) cells, mucosal-associated invariant T cells, and germline-encoded mycolyl-reactive T cells are examples of donor unrestricted T cells.

Conclusions:

Donor unrestricted T cells are common in humans and represent a significant aspect of T cell immunity.
These cells offer alternative therapeutic strategies by bypassing MHC-mediated restrictions.