Hydrogen sulfide in cancer: Friend or foe?

Hydrogen sulfide (H₂S) is the third gaseous signaling molecule that plays important roles in cancer biological processes. Recent studies indicate that H₂S has both pro-cancer and anti-cancer effects. Endogenous H₂S can exert pro-cancer functions through induction of angiogenesis regulation of mitochondrial bioenergetics, acceleration of cell cycle progression, and anti-apoptosis mechanisms. Thus, the inhibition of the production of H₂S in cancer cells may be a new cancer treatment strategy. In contrast to the pro-cancer effect of H₂S, relatively high concentrations of exogenous H₂S could suppress the growth of cancer cells by inducing uncontrolled intracellular acidification, inducing cell cycle arrest, and promoting apoptosis. Therefore, H₂S donors and H₂S-releasing hybrids could be designed and developed as novel anti-cancer drugs. In this review, the production and metabolism of H₂S in cancer cells are summarized and the role and mechanism of H₂S in cancer development and progression are further discussed.