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Bordetella pertussis evolution in the (functional) genomics era.
Thomas Belcher1, Andrew Preston2
1Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.
Pathogens and Disease
|August 23, 2015
Summary
Whooping cough (pertussis) is surging due to Bordetella pertussis adapting to vaccines. Genomics reveals population evolution, highlighting the need for functional genomics to understand vaccine escape and guide future strategies.
Area of Science:
- Microbiology
- Genomics
- Epidemiology
Background:
- Rising incidence of whooping cough (pertussis) in developed nations.
- Association between acellular pertussis vaccine use and increased disease.
- Hypothesized adaptation of Bordetella pertussis under vaccine-induced immune pressure, leading to immune escape.
Purpose of the Study:
- To review the current understanding of Bordetella pertussis evolution and diversity.
- To highlight key questions arising from recent genomic studies.
- To discuss the potential of functional genomics in addressing knowledge gaps.
Main Methods:
- Genomics-based approaches to analyze global B. pertussis population structure.
- Review of recent studies on B. pertussis evolution and diversity.
- Discussion of functional genomics applications.
Main Results:
- Genomic insights reveal fine structure and evolution of B. pertussis during vaccination era.
- Evidence suggests B. pertussis is adapting and potentially escaping vaccine-induced immunity.
- Resurgence linked to vaccine use and bacterial adaptation.
Conclusions:
- Genomic data is crucial for understanding B. pertussis evolution and resurgence.
- Functional genomics is essential to elucidate mechanisms of vaccine escape.
- Further research needed to address knowledge gaps and inform public health strategies.
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