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Updated: Apr 5, 2026

Horizontal Hippocampal Slices of the Mouse Brain
Published on: September 22, 2020
How does the hippocampus shape decisions?
Daniela J Palombo1, Margaret M Keane2, Mieke Verfaellie1
1VA Boston Healthcare System, 150 South Huntington Ave (151A), Boston, MA 02130, United States; Boston University School of Medicine, Department of Psychiatry, 72 E Concord St, Boston, MA 02118, United States.
Abstract:
Making optimal decisions depends on an appreciation of the value of choices. An important source of information about value comes from memory for prior experience. Such value-based learning has historically been considered the domain of a striatal memory system. However, recent developments suggest that memorial representations supported by the hippocampus may also contribute to decision making. Unlike striatal representations, hippocampal ones are flexible; they can be modified and updated as new information is acquired. In this paper we argue that the hippocampus plays a pivotal role in value-based decision making via three flexible learning mechanisms: (1) updating, (2) generalization, and (3) construction.
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