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Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules

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Published on: August 16, 2011

Clonorchiasis.

Men-Bao Qian¹, Jürg Utzinger², Jennifer Keiser³

¹National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, China; World Health Organization Collaborating Center for Tropical Diseases, Shanghai, China.

Lancet (London, England)

|August 25, 2015

Summary

This summary is machine-generated.

Clonorchis sinensis, a liver fluke, causes biliary disorders and cholangiocarcinoma, primarily in East Asia. Advances in -omics have improved diagnostics and identified new drug targets for this parasitic infection.

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Area of Science:

Parasitology
Infectious Diseases
Public Health

Background:

Clonorchis sinensis (C. sinensis) is a liver fluke endemic to East Asia, linked to biliary disorders and cholangiocarcinoma.
Infection is associated with cultural practices like consuming raw freshwater fish, prevalent in the region's socio-ecological systems.

Purpose of the Study:

To review the current understanding of Clonorchiasis, including its lifecycle, clinical features, diagnostics, and epidemiology.
To highlight advancements in -omics sciences for identifying new diagnostic, drug, and vaccine targets.
To discuss current and potential control strategies for C. sinensis infection.

Main Methods:

Literature review of historical and recent studies on Clonorchis sinensis.
Analysis of diagnostic techniques, including the Kato-Katz method.
Evaluation of current and emerging therapeutic agents like praziquantel and tribendimidine.

Main Results:

The lifecycle, pathology, and epidemiology of C. sinensis are better understood, with -omics contributing to new target discovery.
The Kato-Katz technique remains the primary diagnostic tool for C. sinensis.
Praziquantel is the standard treatment, while tribendimidine shows promise in early trials.

Conclusions:

Despite progress, the precise global distribution, prevalence, and burden of clonorchiasis remain undetermined.
Integrated control strategies encompassing preventive chemotherapy, education, environmental management, and intersectoral collaboration are essential.
Further research into pathogenesis and global impact is needed to combat this significant public health issue.