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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
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[A role of long noncoding RNAs in carcinogenesis]
N A Lisitsyn1,2, A A Chernyi1, V L Karpov1
1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.
Molekuliarnaia Biologiia
|August 25, 2015
Summary
This review details how long noncoding RNA (lncRNA) content and function change during cancer development. It also explores using lncRNAs for predicting cancer outcomes.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Context:
- Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in complex biological processes.
- Aberrant lncRNA expression is a hallmark of many human cancers.
- Understanding lncRNA dynamics during carcinogenesis is crucial for advancing cancer research.
Purpose:
- To review the dynamic alterations in lncRNA expression and function across different stages of cancer development.
- To evaluate the potential of lncRNAs as biomarkers for cancer prognosis and therapeutic targets.
Summary:
- This review synthesizes current knowledge on the evolving landscape of lncRNA content and function throughout carcinogenesis.
- It highlights key lncRNAs implicated in tumor initiation, progression, and metastasis.
- The review also discusses the emerging applications of lncRNAs in clinical cancer prognosis.
Impact:
- Provides a comprehensive overview of lncRNA involvement in cancer.
- Identifies potential diagnostic and prognostic biomarkers for improved cancer patient management.
- Suggests future research directions for lncRNA-based cancer therapies.
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