[Quantitative changes in mitochondrial membrane structure of leukemic cells in children with acute leukemia]

The quantitative changes of mitochondrial membrane of AL cells were studied by morphometric technique under electron microscope. We found that the delta sM was 25.0% more increased and the delta mM was 18.0% more decreased in AL than in the controls. The extent of changed of delta mM in C-ALL and N-ALL was much greater than that in T-ALL. We also found that the changing extent of delta mM in AL is related with long term disease-free survival. During the period of inductive therapy, observation on the dynamic changes of delta mM may provide a useful information for predicting the therapeutic effects and the therapeutic scheme individually.