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Updated: Apr 5, 2026
Method for Measurement of Viral Fusion Kinetics at the Single Particle Level
Published on: September 7, 2009
Imaging real-time HIV-1 virion fusion with FRET-based biosensors
Daniel M Jones1, Sergi Padilla-Parra1,2
1Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford OX3 7BN, UK.
Abstract:
We have produced a novel, simple and rapid method utilising genetically encodable FRET-based biosensors to permit the detection of HIV-1 virion fusion in living cells. These biosensors show high sensitivity both spatially and temporally, and allow the real-time recovery of HIV-1 fusion kinetics in both single cells and cell populations simultaneously.
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