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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
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Age-related decrease in CD271(+) cells in human skin.

Hirohiko Akamatsu1, Seiji Hasegawa2,3, Takaaki Yamada1,2,3

  • 1Department of Applied Cell and Regenerative Medicine, Fujita Health University School of Medicine, Aichi, Japan.

The Journal of Dermatology
|August 25, 2015
PubMed
Summary
This summary is machine-generated.

Skin stem cells, identified as CD271(+) cells, decrease with aging. This reduction may impair skin regeneration and contribute to skin diseases, offering potential for future anti-aging and therapeutic developments.

Keywords:
CD271 (p75NTR)agingdermal stem cellepidermal stem cellskin stem cell

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Area of Science:

  • Dermatology
  • Stem Cell Biology
  • Aging Research

Background:

  • Stem cells are crucial for skin homeostasis and regeneration, residing in various skin layers like the epidermis and dermis.
  • CD271(+) cells have been previously identified as key stem cells within skin tissues.
  • Understanding stem cell behavior is vital for addressing skin aging and disease.

Purpose of the Study:

  • To investigate the localization of CD271(+) stem cells in human skin.
  • To examine age-related changes in the number and distribution of these skin stem cells.
  • To explore the implications of these changes for skin health and disease.

Main Methods:

  • Immunohistochemical analysis of human skin samples (epidermis and dermis).
  • Quantification and localization of CD271(+) cells.
  • Comparison of stem cell populations across different age groups.

Main Results:

  • CD271(+) stem cells were found in both the epidermis and dermis of human skin.
  • A significant decrease in the number of CD271(+) cells was observed in the epidermis and dermis with increasing age.
  • This age-related decline suggests a potential link between reduced stem cell numbers and impaired skin function.

Conclusions:

  • The number of CD271(+) skin stem cells diminishes with aging.
  • This reduction may underlie decreased skin regenerative capacity and increased susceptibility to skin diseases.
  • Further research into stem cell aging could pave the way for novel anti-aging and dermatological treatments.