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Published on: March 8, 2015
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Deep Brain Stimulation in Tourette's Syndrome.
1Department of Neurological Sciences, Rush University Medical Center , Chicago, IL , USA.
Frontiers in Neurology
|August 25, 2015
Summary
Deep brain stimulation (DBS) is a safe and feasible treatment for Tourette Syndrome (TS) when conventional therapies fail. Further research is needed to optimize DBS targets and patient selection for tic reduction.
Area of Science:
- Neurology
- Neurosurgery
Background:
- Tourette Syndrome (TS) is characterized by persistent motor and vocal tics.
- Conventional treatments are often ineffective for refractory TS.
- Deep brain stimulation (DBS) presents a potential intervention for severe cases.
Purpose of the Study:
- To review DBS targets for TS.
- To evaluate the efficacy and adverse effects of DBS in TS.
- To discuss patient selection and future directions for DBS in TS.
Main Methods:
- Literature review of PubMed database (2000-2015).
- Search terms included "DBS in Tourette Syndrome" and related phrases.
- Analysis of existing evidence on DBS for TS.
Main Results:
- Patient selection for DBS in TS considers age, tic severity, and treatment resistance.
- Thalamic and globus pallidus internus (GPi) are the most studied DBS targets.
- Small trials indicate DBS efficacy, with manageable psychiatric side effects.
Conclusions:
- DBS is a safe and feasible option for Tourette Syndrome.
- Further large-scale, multi-center trials are required.
- Optimal DBS targets and anatomical locations need further determination.
