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Related Concept Videos

Complement System01:27

Complement System

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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Antimicrobial Proteins01:23

Antimicrobial Proteins

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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
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Regulation of Metabolism01:19

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Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Liver Physiology01:30

Liver Physiology

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
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Complementation Tests00:49

Complementation Tests

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A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
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Related Experiment Video

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Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
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Complement regulation: physiology and disease relevance.

Heeyeon Cho1

  • 1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Korean Journal of Pediatrics
|August 25, 2015
PubMed
Summary
This summary is machine-generated.

The complement system protects the body but needs regulation to prevent self-damage. Understanding complement regulators is key to treating autoimmune diseases.

Keywords:
AutoimmunityComplement

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High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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Depletion of Specific Cell Populations by Complement Depletion
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Related Experiment Videos

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Depletion of Specific Cell Populations by Complement Depletion
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Area of Science:

  • Immunology
  • Molecular Biology

Background:

  • The complement system is a crucial part of innate immunity, defending against pathogens and clearing cellular debris.
  • Maintaining a balance between complement activation and inhibition is vital for host health, preventing damage to self-cells.
  • Complement regulators, both soluble and membrane-bound, are essential for this balance.

Purpose of the Study:

  • To highlight the critical role of complement regulators in immune homeostasis.
  • To underscore the link between defective complement regulation and autoimmune diseases.
  • To emphasize the importance of understanding regulatory mechanisms for therapeutic development.

Main Methods:

  • Review of existing literature on complement system function and regulation.
  • Analysis of the consequences of defective complement regulators.
  • Correlation of complement dysregulation with specific autoimmune conditions.

Main Results:

  • Defective complement regulators can lead to host cell damage and accumulation of immunological debris.
  • Dysfunctional complement regulation is implicated in autoimmune diseases like atypical hemolytic uremic syndrome, dense deposit disease, age-related macular degeneration, and systemic lupus erythematosus.

Conclusions:

  • Understanding the molecular mechanisms of complement regulation is crucial.
  • Targeting complement regulatory pathways offers potential for novel therapies for complement-associated diseases.