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Ventricular repolarization markers for predicting malignant arrhythmias in clinical practice
Yaniel Castro-Torres1, Raimundo Carmona-Puerta1, Richard E Katholi1
1Yaniel Castro-Torres, Facultad de Medicina, Universidad de Ciencias Médicas Dr. Serafín Ruiz de Zárate Ruiz, Santa Clara 50200, Villa Clara, Cuba.
World Journal of Clinical Cases
|August 25, 2015
Summary
Predicting sudden cardiac death from malignant arrhythmias is challenging. Ventricular repolarization (VR) markers from ECGs show promise for risk stratification in various conditions, but more research is needed for consensus.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Diagnostics
Background:
- Malignant cardiac arrhythmias leading to sudden cardiac death pose a significant clinical challenge.
- Predicting these events is difficult, especially in seemingly healthy individuals or those with underlying conditions.
Purpose of the Study:
- To review the utility of ventricular repolarization (VR) markers in predicting malignant cardiac arrhythmias.
- To discuss the pathophysiological mechanisms underlying arrhythmogenic predisposition and VR marker basis.
Main Methods:
- Analysis of existing literature on VR markers derived from 12-lead surface electrocardiograms.
- Discussion of specific VR markers including corrected QT, QT dispersion, Tpeak-Tend, Tpeak-Tend dispersion, and Tp-e/QT.
Main Results:
- Several VR markers have demonstrated effectiveness in predicting malignant arrhythmias across diverse conditions.
- These include long and short QT syndromes, Brugada syndrome, early repolarization syndrome, myocardial ischemia, heart failure, hypertension, diabetes, obesity, and athletes.
Conclusions:
- VR markers show potential for risk stratification in various clinical scenarios.
- Further research and global consensus are required for widespread clinical integration of these parameters.
Keywords:
Corrected QT intervalElectrocardiographic predictorQT dispersionQT intervalSudden cardiac deathTpeak-Tend QT ratioTpeak-Tend intervalVentricular fibrillationVentricular repolarization markersMore Related Videos
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