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Preparation of Light-responsive Membranes by a Combined Surface Grafting and Postmodification Process

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Versatile and Rapid Postfunctionalization from Cyclodextrin Modified Host Polymeric Membrane Substrate.

Jie Deng¹, Xinyue Liu¹, Shuqing Zhang¹

¹College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University , Chengdu 610065, China.

Langmuir : the ACS Journal of Surfaces and Colloids

|August 25, 2015

Summary

This summary is machine-generated.

This study presents a novel method for modifying polymeric membranes using beta-cyclodextrin (β-CD) and adamantane (Ad) host-guest interactions. This versatile surface modification imparts anticoagulant, antifouling, and antibacterial properties to membranes for advanced bioimplant applications.

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Area of Science:

Materials Science
Biomaterials Engineering
Polymer Chemistry

Background:

Surface modification of bioimplants is crucial for imparting desired functionalities.
Existing surface modification technologies have limitations in efficiency and versatility.
Novel protocols are needed to efficiently functionalize inert material surfaces.

Purpose of the Study:

To develop a versatile and rapid postfunctionalization strategy for polymeric membranes.
To fabricate β-cyclodextrin (β-CD) modified membranes capable of recognizing specific guest macromolecules.
To create multifunctional membranes with anticoagulant, antifouling, and antibacterial properties.

Main Methods:

Fabrication of epoxy-enriched poly(ether sulfone) (PES) membranes.
Immobilization of β-cyclodextrin (β-CD) onto the PES membrane surface via host-guest interactions with adamantane (Ad).
Assembly of Ad-terminated polymers (Ad-PSA, Ad-PEG, Ad-PMT) to impart specific functionalities.

Main Results:

Successfully created β-CD immobilized membranes (PES-CD) using a two-step process.
Demonstrated versatile postfunctionalization by attaching different Ad-terminated polymers.
Achieved anticoagulant, antifouling, and antibacterial properties as confirmed by various assays (APTT, TT, PT, protein adsorption, platelet adhesion, S. aureus inhibition).

Conclusions:

The proposed host-guest interaction strategy enables rapid and versatile postfunctionalization of polymeric membranes.
The functionalized membranes exhibit well-regulated blood compatibility, antifouling, and bactericidal activities.
This approach offers a promising route for preparing multifunctional polymeric membrane materials for diverse bioimplant applications.