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Improving Medication Adherence in Patients with Hypertension: A Randomized Trial
Ulla Hedegaard1, Lene Juel Kjeldsen2, Anton Pottegård3
1Clinical Pharmacology, Department of Public Health, University of Southern Denmark, Odense, Denmark; Clinical Pharmacy Department, Hospital Pharmacy of Funen, Odense University Hospital, Odense, Denmark.
The American Journal of Medicine
|August 25, 2015
Summary
A pharmacist intervention improved medication adherence in hypertensive patients. This study highlights the impact of tailored counseling on managing chronic conditions and reducing cardiovascular risks.
Area of Science:
- Cardiology
- Pharmacology
- Public Health
Background:
- Suboptimal medication adherence in hypertension increases risks of ischemic heart disease and stroke.
- Pharmacist interventions can potentially improve adherence in managing chronic conditions.
Purpose of the Study:
- To evaluate a multifaceted pharmacist intervention's effectiveness in improving medication adherence among hypertensive patients.
- To assess the impact of motivational interviewing and collaborative care on adherence.
Main Methods:
- A randomized trial involving 532 hypertensive patients comparing usual care with a 6-month pharmacist intervention.
- Intervention included collaborative care, medication review, adherence counseling with motivational interviewing, and telephone follow-ups.
- Primary outcome: composite medication possession ratio (MPR) at 1-year follow-up.
Main Results:
- The pharmacist intervention group showed significantly improved medication adherence (median MPR 0.93 vs. 0.91, P = .02).
- Nonadherence rates were lower in the intervention group (20.3%) compared to the control group (30.2%).
- No significant differences observed in blood pressure, persistence, or hospital admissions between groups.
Conclusions:
- A multifaceted hospital-based pharmacist intervention effectively improved sustained medication adherence in hypertensive patients.
- The intervention did not significantly impact blood pressure or secondary clinical outcomes.
- Pharmacist-led interventions show promise for enhancing medication adherence in chronic disease management.
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