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Related Concept Videos

Autophagy01:27

Autophagy

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Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
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Delivery Pathways to the Lysosome01:36

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
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Autophagic Cell Death01:18

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Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
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Related Experiment Video

Updated: Apr 5, 2026

Author Spotlight: In-Depth Morphometric Examination and Quantification of Native Lens Structure Using Whole Mount Imaging
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Author Spotlight: In-Depth Morphometric Examination and Quantification of Native Lens Structure Using Whole Mount Imaging

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Autophagy in the lens.

Hideaki Morishita1, Noboru Mizushima1

  • 1Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.

Experimental Eye Research
|August 25, 2015
PubMed
Summary

Autophagy is crucial for lens cell quality control but not essential for organelle removal. This review explores autophagy

Area of Science:

  • Cellular Biology
  • Ophthalmology
  • Molecular Biology

Background:

  • The eye lens requires organelle degradation for transparency.
  • Autophagy, a cellular degradation pathway, is active in the lens.
  • The exact role of autophagy in lens organelle degradation is unclear.

Purpose of the Study:

  • To review the function of autophagy and lysosomes in the lens.
  • To discuss their roles in intracellular quality control.
  • To explore their potential involvement in human cataract development.

Main Methods:

  • Literature review of recent genetic studies in mice.
  • Analysis of findings on autophagy and lysosome function.
  • Discussion of implications for lens biology and disease.
Keywords:
AutophagyCataractIntracellular quality controlLensOrganelle degradation

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Main Results:

  • Autophagy is essential for maintaining lens intracellular quality control.
  • Autophagy may not be required for the degradation of lens organelles.
  • Lysosomes play a role in lens homeostasis.

Conclusions:

  • Autophagy is vital for lens intracellular quality control.
  • Further research is needed to clarify autophagy's role in organelle degradation.
  • Dysregulation of autophagy and lysosomes may contribute to cataract formation.