Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

1.3K
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
1.3K
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

793
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
793
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

1.4K
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
1.4K
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

888
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
888
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

1.3K
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
1.3K
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

997
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
997

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimising patient positioning in magnetic resonance imaging for image Co-registration in radiosurgery planning.

Radiography (London, England : 1995)·2025
Same author

Effects of European authorised level of zinc from different sources on the physiology and intestinal ecosystem and performance of piglets weaned at different ages.

Veterinary and animal science·2025
Same author

Holistic evaluation of the environmental impacts of shipping in the sensitive region of Ria de Aveiro.

The Science of the total environment·2024
Same author

Biochemical analysis of three red grapevine varieties during three phenological periods grown under Mediterranean climate conditions.

Plant biology (Stuttgart, Germany)·2024
Same author

Bone characteristics, pre-caecal phytate degradation, mineral digestibility and tissue expression were marginally affected by zinc level and source in phytase-supplemented diets in 21-day-old broiler chickens.

British poultry science·2024
Same author

Replacing soybean meal with microalgae biomass in diets with contrasting carbohydrate profiles can reduce in vitro methane production and improve short-chain fatty acid production.

Journal of dairy science·2024

Related Experiment Video

Updated: Apr 5, 2026

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

3.3K

Slow transit constipation and lower urinary tract dysfunction.

V Queiroz Machado1, A Monteiro2, A Peçanha2

  • 1Department of Pediatrics, The School of Medical Sciences, The University of the State of Rio de Janeiro, Boulevard 28 de Setembro, 77 Vila Isabel, 20 551-030, Rio de Janeiro, Brazil.

Journal of Pediatric Urology
|August 26, 2015
PubMed
Summary
This summary is machine-generated.

Children with refractory constipation and lower urinary tract symptoms often have slow transit constipation (STC). This suggests a potential common neuromuscular disorder affecting both bladder and bowel function.

Keywords:
Bladder and bowel dysfunctionCajal cellsChildrenDetrusor overactivitySlow transit constipationUrinary incontinence

More Related Videos

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

1.2K
Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

2.2K

Related Experiment Videos

Last Updated: Apr 5, 2026

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

3.3K
Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

1.2K
Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

2.2K

Area of Science:

  • Pediatric Gastroenterology
  • Pediatric Urology
  • Neuromuscular Disorders

Background:

  • Constipation and lower urinary tract dysfunction (LUTD) often coexist in children.
  • Theories suggest rectal distension or sacral reflex stimulation as causes.
  • Refractory constipation may indicate underlying colon motility defects, suggesting a common neuromuscular basis for bladder and bowel dysfunction (BBD).

Purpose of the Study:

  • To investigate colonic transit time (CTT) in pediatric patients with refractory constipation and lower urinary tract symptoms (LUTS).

Main Methods:

  • Evaluated 15 children with refractory constipation and LUTS using medical history, physical exams, bladder/bowel diaries, stool/dysfunction scoring, ultrasound, and urodynamic evaluation.
  • Colonic transit time (CTT) was measured using radiopaque markers.

Main Results:

  • Abnormal urodynamic features were present in 13/15 children, including detrusor overactivity (DO) and voiding dysfunction (VD).
  • CTT studies revealed abnormalities in 12/15 children, with slow transit constipation (STC) being the most common (9/15).
  • STC was significantly associated with DO (P=0.04) and higher Dysfunctional Voiding Scoring System (DVSS) scores.

Conclusions:

  • A high prevalence of STC was observed in children with refractory constipation and LUTS.
  • Detrusor overactivity (DO) showed a significant association with STC.
  • Findings support the hypothesis of a common neuromuscular disorder underlying both bladder and bowel dysmotility.