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Updated: Apr 5, 2026

Spin Saturation Transfer Difference NMR SSTD NMR: A New Tool to Obtain Kinetic Parameters of Chemical Exchange Processes
Published on: November 12, 2016
Refinement of the inversion-transfer NMR experiment for faster characterization of chemical exchange
1CEISAM CNRS UMR 6230, Département de Chimie, Université de Nantes, 2 rue de la Houssiniére, F-44322 Nantes cedex 3, France.
Abstract:
It is shown theoretically that the inversion-transfer experiment used to estimate the value of unidirectional rate constants in chemical exchange systems can be performed faster via a reduction of the recovery delay. The chemical exchange rate constants can then be estimated accurately with a formula close to that of standard inversion transfer and easy to use, after a justified approximation. A function was developed to determine the optimal value of the recovery delay for an optimal inversion-transfer sequence. The validity of these theoretical results was checked experimentally with a solution of N,N-dimethylacetamide in which chemical exchange arises from internal hindered rotation.
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