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Improvement of malignant pleural mesothelioma immunotherapy by epigenetic modulators

Malik Hamaidia, Bernard Staumont, Bernard Duysinx

  • 1Department of AgroBioChem, University of Liege, 5030, Gembloux, Belgium. luc.willems@ulg.ac.be.

Current Topics in Medicinal Chemistry
|August 26, 2015
PubMed

In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor specificity and good tolerability. Unfortunately, MPM immunotherapy is frequently limited by incomplete cell differentiation or feedback loop regulatory mechanisms. In this review, we describe different components of the innate immune system and discuss strategies to improve MPM immunotherapy by using epigenetic modulators.

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