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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
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Modified-Release Drug Delivery Systems: Influencing Factors01:20

Modified-Release Drug Delivery Systems: Influencing Factors

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Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

213
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
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Biopolymer-Based Delivery Systems: Challenges and Opportunities.

Iris J Joye, D Julian McClements1

  • 1Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA. mcclements@foodsci.umass.edu.

Current Topics in Medicinal Chemistry
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Summary

Biopolymer particles offer tailored colloidal delivery systems for various industries. Challenges in biopolymer variability impact particle attributes, but opportunities exist for food-grade applications.

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Area of Science:

  • Materials Science
  • Colloid Science
  • Biotechnology

Background:

  • Biopolymer-based nanostructures and microstructures are versatile for colloidal delivery systems.
  • Applications span agriculture, food, supplements, personal care, and pharmaceuticals.
  • Biopolymer complexity presents challenges in achieving consistent particle properties.

Purpose of the Study:

  • To review biopolymer properties relevant to particle fabrication.
  • To discuss common methods for assembling biopolymer-based particles.
  • To identify challenges and opportunities in developing food-grade biopolymer delivery systems.

Main Methods:

  • Electrospinning
  • Coacervation
  • Nanoprecipitation
  • Injection
  • Layer-by-layer deposition
  • Gelation

Main Results:

  • Fabrication methods allow tailoring of composition, structure, and properties.
  • Biopolymer variability complicates the production of particles with defined attributes.
  • Potential exists for optimized biopolymer particles in food-grade delivery.

Conclusions:

  • Biopolymer-based particles are promising for controlled release applications.
  • Addressing biopolymer variability is key to advancing particle technology.
  • Further research can unlock the full potential of these systems for food applications.