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Updated: Apr 5, 2026
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Multiple primary melanoma in the elderly
Adam C Krajewski1, Donna R Hart2, Tina J Hieken3
1Department of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Background:
Few data exist regarding surveillance for multiple primary melanoma (MPM) in elderly patients or whether the incidence and risk factors are the same as for younger patients. Thus, we studied the frequency and characteristics of MPM in the elderly melanoma patients.
Methods:
From our prospective melanoma registry, we studied 222 consecutive patients aged 65 years or older at their initial melanoma diagnosis. Mean follow-up was 65 ± 3 months.
Results:
Median age was 76 years. Twenty-two patients (10%) developed a second primary melanoma and 8 (4%) of 3 or more primaries. 82% of second primaries (18 of 22) were the same or thinner than the index melanoma, yet 50% of third primary melanomas (4 out of 8) were thicker. Only prior dysplastic nevi (P <. 0001) were a significant risk factor for MPM.
Conclusions:
These data suggest elderly melanoma patients have a significant risk of MPM that warrants careful surveillance to facilitate prompt detection and treatment. Patients with dysplastic nevi merit special scrutiny.
