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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Updated: Apr 5, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Multiple primary melanoma in the elderly.

Adam C Krajewski¹, Donna R Hart², Tina J Hieken³

¹Department of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

American Journal of Surgery

|August 26, 2015

Summary

This summary is machine-generated.

Elderly patients diagnosed with melanoma have a significant risk of developing multiple primary melanomas (MPM). Prior dysplastic nevi are a key risk factor, necessitating vigilant surveillance in older adults.

Keywords:

Dysplastic nevi Elderly Melanoma Multiple primary melanoma

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Area of Science:

Dermatology
Oncology
Geriatrics

Background:

Limited data exist on multiple primary melanoma (MPM) surveillance in elderly populations.
Investigating whether incidence and risk factors for MPM differ in older versus younger patients.

Purpose of the Study:

To determine the frequency and characteristics of MPM in patients aged 65 and older.
To identify risk factors associated with MPM in the elderly melanoma population.

Main Methods:

Prospective melanoma registry analysis of 222 consecutive patients aged 65+ at initial diagnosis.
Mean follow-up duration of 65 ± 3 months.

Main Results:

10% of elderly patients developed a second primary melanoma; 4% developed three or more.
Second primary melanomas were often similar or thinner than the initial melanoma.
Third primary melanomas were more frequently thicker; prior dysplastic nevi were a significant risk factor (P <.0001).

Conclusions:

Elderly melanoma patients face a substantial risk of MPM, underscoring the need for careful surveillance.
Prompt detection and treatment are crucial for managing MPM in older adults.
Patients with a history of dysplastic nevi require heightened scrutiny for MPM.