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A novel gemycircularvirus from experimental rats
1Department of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.
Abstract:
Recently, gemycircularviruses have been found in humans and various species of animals. Here, a novel gemycircularvirus named Ch-zjrat-01 from blood samples of experimental rats was characterized. The novel gemycircularvirus encodes two major proteins, including a capsid protein (Cap) and a replication-associated protein (Rep). Phylogenetic analysis based on the amino acid sequence of Rep indicated that Ch-zjrat-01 clusters with two gemycircularviruses discovered from bird (KF371635) and mosquito (HQ335086), sharing 48.7 and 49.4 % sequence identities with them, respectively.
Insights
A novel gemycircularvirus, Ch-zjrat-01, was identified in experimental rats. This discovery expands the known hosts for gemycircularviruses, with implications for animal and potentially human health.
Area of Science:
- Virology
- Molecular Biology
- Animal Health
Background:
- Gemycircularviruses are increasingly detected across diverse hosts, including humans and animals.
- The host range and genetic diversity of gemycircularviruses remain incompletely understood.
Purpose of the Study:
- To characterize a novel gemycircularvirus identified in experimental rats.
- To determine the genetic relationship of this new virus to known gemycircularviruses.
Main Methods:
- Viral DNA isolation from rat blood samples.
- Genome sequencing and analysis.
- Phylogenetic analysis of viral proteins.
Main Results:
- Identification and characterization of a novel gemycircularvirus, designated Ch-zjrat-01.
- The virus encodes two main proteins: capsid protein (Cap) and replication-associated protein (Rep).
- Phylogenetic analysis revealed Ch-zjrat-01 is most closely related to gemycircularviruses found in birds and mosquitoes, with sequence identities of 48.7% and 49.4% respectively.
Conclusions:
- This study reports the first gemycircularvirus identified in experimental rats.
- The findings contribute to understanding the broader host tropism and genetic diversity of gemycircularviruses.
- Further research is warranted to assess the potential impact of Ch-zjrat-01 on rat health and its zoonotic potential.