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Intraocular myofibroblastoma in an infant: a case report
Ning Hua1, Jinyong Lin2, Xuehan Qian3
1Tianjin Medical University Eye Hospital, Tianjin, China. 0133_cn@sina.com.
Insights
A rare intraocular myofibroblastoma in an infant was successfully resected. This benign spindle cell tumor requires precise histopathological and immunohistochemical diagnosis for accurate identification.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Surgical Pathology
Background:
- Myofibroblastoma is a benign tumor characterized by spindle cells and hyalinized collagen.
- Intraocular myofibroblastoma is an exceedingly rare condition, particularly in infants.
Observation:
- A 4-month-old female infant presented with suspected corneal perforation due to a right eye neoplasm.
- Color Doppler ultrasonography indicated anterior segment involvement.
- Surgical exploration and resection of the protuberant mass were performed.
Findings:
- Histopathological examination revealed spindle-shaped cells and collagen bands beneath corneal epithelia.
- Immunohistochemical staining showed strong positivity for vimentin and smooth muscle actin, and negativity for S-100 protein.
- The mass was definitively diagnosed as myofibroblastoma.
Implications:
- Intraocular myofibroblastoma can present with complex manifestations, potentially leading to misdiagnosis as other congenital anomalies.
- Accurate diagnosis relies heavily on histopathological and immunohistochemical analysis.
- The resected tumor showed no recurrence after a 12-month follow-up period.
Background:
Myofibroblastoma is a benign tumor composed of spindle cells and bands of hyalinized collagen. Intraocular myofibroblastoma in infancy is rarely encountered.
Case Presentation:
The present study reports the case of a 4-month-old female baby with intraocular myofibroblastoma. She was suspected as corneal perforation due to the rupture of a corneal neoplasm in the right eye. The anterior segment was also involved according to the Color Doppler ultrasonography. A surgical exploration was performed and the protuberant part of the mass was resected. Conventional HE staining showed numerous spindle-shaped cells with bands of collagen beneath multilayers of well-differentiated corneal epithelia. Immunohistochemical staining demonstrated the tumor cells were strong positive for vimentin and smooth muscle actin, while negative for S-100 protein. The mass was confirmed as myofibroblastoma. After 12 month follow-up, there was no apparent growth of the tumor.
Conclusions:
Myofibroblastoma is a very rare type of intraocular neoplasm, which may have complicated manifestation and could be misdiagnosed as dermoid or Peter's anomaly. Histopathological and immunohistochemical staining is crucial to form a precise diagnosis.
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