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Related Experiment Video

Updated: Apr 5, 2026

Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord
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Perivascular Mesenchymal Stem Cells From the Adult Human Brain Harbor No Instrinsic Neuroectodermal but High

Xenia Lojewski1, Sumitra Srimasorn1, Juliane Rauh1

  • 1Division of Neurodegenerative Diseases, Department of Neurology, University Center for Orthopaedics and Trauma Surgery and Center for Translational Bone, Joint and Soft Tissue Research, Department of Medicine I, Faculty of Medicine, and Department of Neurosurgery, Technische Universität Dresden, Dresden, Germany; Department of Biomedicine, University of Basel, Basel, Switzerland; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Department for Translational Neurodegeneration, Technical University of Munich, German Centre for Neurodegenerative Diseases, Munich, Germany; Geriatric Hospital Haag, Haag, Germany; Department of Neurology, Technical University of Munich, Munich, Germany; Center for Regenerative Therapies Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases Dresden, Dresden, Germany.

Stem Cells Translational Medicine
|August 26, 2015
PubMed
Summary

Adult human brain perivascular cells are a novel mesodermal cell type with potential for cell therapy. These cells resemble bone marrow mesenchymal stem cells (MSCs) and may be useful for treating neurological diseases.

Keywords:
Brain pericytesBrain perivascular cellsHippocampusMonolayer cultureNeural progenitor cellsWhite matter

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Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Brain perivascular cells, a novel mesodermal cell type, reside in the human brain's perivascular niche.
  • Mesenchymal stem cells (MSCs) are investigated for cell therapy in neurological disorders.
  • Understanding the intrinsic MSC population in the human brain is crucial for therapeutic applications.

Purpose of the Study:

  • To systematically characterize adult human brain-derived pericytes.
  • To compare brain pericytes with neural stem cells (NSCs) and bone marrow-derived MSCs.
  • To evaluate the differentiation potential of brain pericytes.

Main Methods:

  • Isolation and in vitro expansion of adult human brain pericytes from hippocampus and subcortical white matter.
  • Comparison of pericytes with fetal/adult human brain-derived NSCs and adult human bone marrow-derived MSCs.
  • Analysis of surface marker expression, whole transcriptome profile, and differentiation potential (neuroectodermal and mesodermal).

Main Results:

  • Adult human brain pericytes are easily expandable in monolayer cultures, unlike adult human NSCs.
  • Brain pericytes exhibit surface marker expression and transcriptome profiles similar to human bone marrow-derived MSCs.
  • Pericytes show negligible neuroectodermal differentiation but efficient mesodermal differentiation.

Conclusions:

  • Adult human brain pericytes resemble bone marrow-derived MSCs.
  • These cells possess significant mesodermal differentiation potential.
  • Brain pericytes are of interest for autologous stem cell-based strategies in neurological disease treatment.