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Updated: Apr 5, 2026

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
Published on: March 17, 2022
Management of Right Heart Failure in the Intensive Care Unit
Cyrus A Kholdani1, Wassim H Fares1
1Pulmonary Vascular Disease Program, Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, 15 York Street, LCI 105, New Haven, CT 06510, USA.
Abstract:
Right heart failure is a clinical syndrome of various causes that commonly involves failure of the right ventricle (RV). The hemodynamic hallmark of the syndrome is increasing central venous pressure and worsening cardiac output with a rising RV end-diastolic pressure. When dealing with RV failure, clinicians must assess and optimize the intravascular volume state, support RV contractility, and address any pathologic elevations of afterload so that systemic perfusion is preserved. Despite these measures, there may still be a need to offer rescue interventions to the failing RV in carefully selected patients.
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