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Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia.

C Michel Zwaan¹, Edward A Kolb¹, Dirk Reinhardt¹

¹C. Michel Zwaan, Marry M. van den Heuvel-Eibrink, Sophia Children's Hospital/Erasmus MC, Rotterdam; C. Michel Zwaan, International Berlin-Frankfurt-Münster Study Group (I-BFM-SG) New Agents Committee; C. Michel Zwaan, Innovative Therapies for Children With Cancer Consortium; C. Michel Zwaan, Eveline S.J.M. De Bont, Marry M. van den Heuvel-Eibrink, Gertjan J.L. Kaspers, Dutch Childhood Oncology Group, Den Haag; Eveline S.J.M. De Bont, University of Groningen, University Medical Center Groningen, Groningen; Marry M. van den Heuvel-Eibrink, Gertjan J.L. Kaspers, Princess Máxima Center for Pediatric Oncology, Utrecht; Gertjan J.L. Kaspers, Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Edward A. Kolb, Nemours/Alfred I. du Pont Hospital for Children, Wilmington, DE; Edward A. Kolb, Richard Aplenc, Lilian Sung, Children's Oncology Group, Monrovia, CA; Dirk Reinhardt, Universitäts-Klinikum, Essen; Ursula Creutzig, Hannover Medical School, Hannover; Dirk Reinhardt, Michael Dworzak, Henrik Hasle, Ursula Creutzig, Gertjan J.L. Kaspers, I-BFM Acute Myeloid Leukemia (AML) Study Group, Kiel, Germany; Jonas Abrahamsson, Sahlgrenska University Hospital, Goteborg; Jonas Abrahamsson and Henrik Hasle, Nordic Society for Pediatric Hematology and Oncology, Stockholm, Sweden; Souichi Adachi, Kyoto University, Kyoto; Souichi Adachi, Daisuke Tomizawa, The Japanese Pediatric Leukemia/Lymphoma Study Group, Nagoya; Daisuke Tomizawa, National Center for Child Health and Development, Tokyo, Japan; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Barbara De Moerloose, Ghent University Hospital and Belgian Society of Paediatric Haematology Oncology, Ghent, Belgium; Michael Dworzak, St Anna Children's Hospital and Children's Cancer Research Institute, Medical University of Vienna, Vienna, Austria; Brenda E.S. Gibson, Royal Hospital for Sick Children, Glasgow; Brenda E.S. Gibson and Owen Smith, Children's Cancer and Leukemia Study Group, London, United King

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology

|August 26, 2015

Summary

Pediatric acute myeloid leukemia (AML) research has advanced significantly due to global collaboration. Future efforts focus on innovative therapies to cure childhood AML with fewer side effects.

Area of Science:

Hematology
Pediatric Oncology
Cancer Research

Background:

Pediatric acute myeloid leukemia (AML) is a rare childhood cancer with approximately 7 cases per million children annually.
Significant progress in diagnosis, treatment, and outcome monitoring has been achieved over recent decades.
The rarity of pediatric AML necessitates national and international collaborative research efforts.

Observation:

This overview details the history and contributions of major global pediatric AML collaborative groups.
It focuses on translational and clinical research, encompassing past, current, and future clinical trials.
Specific sections address acute promyelocytic leukemia, myeloid leukemia in Down syndrome, and relapsed AML.

Findings:

Numerous novel antileukemic agents and new drug classes have emerged.
Supportive care and late effects are critical components of pediatric AML treatment.
International collaboration is expanding, driving innovative therapies.

Implications:

The future of pediatric AML treatment is promising, with a focus on curing all children.
Emerging therapies aim to minimize adverse effects and long-term complications.
Continued global collaboration is essential for advancing pediatric AML research and patient outcomes.

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