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Related Concept Videos

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

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Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
79
Development of Human Microbiota01:30

Development of Human Microbiota

37
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
37
The Oral Microbiota01:27

The Oral Microbiota

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The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
41
Microbiota of the Urogenital Tract01:28

Microbiota of the Urogenital Tract

41
The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
41
Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

36
The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
36
The Skin Microbiota01:27

The Skin Microbiota

55
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
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[The human microbiome].

Daniel C Baumgart1

  • 1Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie der Charité Berlin.

Deutsche Medizinische Wochenschrift (1946)
|August 26, 2015
PubMed
Summary
This summary is machine-generated.

Understanding the human microbiome offers insights into diseases. Interdisciplinary research, including bioinformatics, is crucial for translating findings into clinical applications, especially for treatments like fecal microbial transplantation (FMT).

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Area of Science:

  • Microbiology
  • Genetics
  • Bioinformatics
  • Translational Medicine

Background:

  • The human microbiome plays a significant role in inflammatory, metabolic, and malignant diseases.
  • Research complexity necessitates an interdisciplinary, translational approach integrating bioinformatics.
  • Pure in silico analyses and statistical associations require careful translation into clinical concepts.

Purpose of the Study:

  • To highlight the importance of an interdisciplinary translational approach in microbiome research.
  • To identify potential therapeutic targets including nutrition, medication, and microbial metabolites.
  • To emphasize the need for rigorous evaluation of fecal microbial transplantation (FMT) before clinical adoption.

Main Methods:

  • Interdisciplinary translational research approach.
  • Bioinformatic analysis.
  • Clinical trial evaluation of investigational treatments.

Main Results:

  • Nutrition and medication demonstrably impact microbial diversity.
  • Microbial metabolic processes and metabolites show therapeutic potential.
  • Fecal microbial transplantation (FMT) requires stringent evaluation for efficacy and safety.

Conclusions:

  • An integrated approach is essential for advancing microbiome research and clinical application.
  • Microbiome-targeted therapies hold promise for various diseases.
  • Fecal microbial transplantation (FMT) must undergo thorough clinical investigation and regulatory scrutiny akin to other treatments.