Search research articles

Related Concept Videos

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

Inflammation

Inflammation

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CircRNA circdner mediates histone lactylation modification via glutamine metabolic reprogramming to regulate PD-L1 expression and promote immune evasion in lung cancer.

World journal of surgical oncology·2025

Same author

Hepatic-specific vitamin D receptor downregulation alleviates aging-related metabolic dysfunction-associated steatotic liver disease.

World journal of gastroenterology·2025

Same author

Auxin Orchestrates Germ Cell Specification in <i>Arabidopsis</i>.

International journal of molecular sciences·2025

Same author

The Small Molecules of Plant Origin with Anti-Glioma Activity.

International journal of molecular sciences·2025

Same author

Feeding tube self-management experience of patients at home after discharge following esophageal cancer surgery.

World journal of gastrointestinal surgery·2025

Same author

A short-course of low-dose insulin detemir effectively decreases blood glucose levels in gestational diabetic women undergoing dexamethasone treatment to promote newborn lung maturity.

Medicine·2025

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Apr 5, 2026

Quantification of Atherosclerosis in Mice

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

Apple Polyphenols Decrease Atherosclerosis and Hepatic Steatosis in ApoE-/- Mice through the ROS/MAPK/NF-κB Pathway.

Zhe-Rong Xu¹, Jin-You Li², Xin-Wei Dong³

¹Department of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China. xuzherong@yeah.net.

|August 26, 2015

Summary

Apple polyphenols (APs) significantly reduce atherosclerosis, hyperlipidemia, and hepatic steatosis in mice. APs also improve endothelial function by suppressing inflammatory pathways and enhancing antioxidant defenses, suggesting their potential as a nutritional supplement.

Keywords:

ApoE−/−mice apple polyphenols atherosclerosis atorvastatin hepatic steatosis oxidative stress vascular Inflammation western-type diet

More Related Videos

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

Related Experiment Videos

Last Updated: Apr 5, 2026

Quantification of Atherosclerosis in Mice

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

Area of Science:

Cardiovascular Research
Nutritional Science
Biochemistry

Background:

Atherosclerosis, hyperlipidemia, and hepatic steatosis are major health concerns.
Dietary interventions are crucial for managing these conditions.
Apple polyphenols (APs) show potential health benefits, but their mechanisms require further investigation.

Purpose of the Study:

To investigate the effects of apple polyphenols (APs) on hyperlipidemia, atherosclerosis, hepatic steatosis, and endothelial function.
To elucidate the underlying mechanisms of APs' action.
To compare the efficacy of APs with atorvastatin.

Main Methods:

ApoE(-/-) mice were fed a western-type diet and treated with APs (100 mg/kg) or atorvastatin (10 mg/kg) for 12 weeks.
Measurements included atherosclerotic lesions, hepatic steatosis, plasma lipid profiles, and inflammatory markers.
Gene expression analysis and in vitro assays on rat aortic endothelial cells (RAECs) were performed.

Main Results:

APs and atorvastatin significantly reduced atherosclerotic lesions, hepatic steatosis, and plasma levels of LDL, triglycerides, CCL-2, and VCAM-1.
APs increased HDL cholesterol and upregulated antioxidant enzymes (GPx, CAT, SOD) in the liver.
APs modulated lipid metabolism by regulating PPARα, SCAP, and related genes, and suppressed the ROS/MAPK/NF-κB pathway.

Conclusions:

Apple polyphenols (APs) demonstrate significant efficacy in attenuating hyperlipidemia, atherosclerosis, and hepatic steatosis.
APs improve endothelial function and reduce inflammation through antioxidant and anti-inflammatory mechanisms.
APs represent a promising nutritional supplement for cardiovascular health.