Microvascular distribution in normal human synovium

The distribution of vessels in normal human synovium has been investigated using frozen sections and staining with Ulex Europaeus lectin by an indirect immunoperoxidase technique. The presence of a vascular net close to the tissue surface was confirmed. Quantitative analysis showed the majority of vessel profiles to be small venules with a peak density 25-100 microns beneath the tissue surface. A smaller number of capillaries was present with a peak density within 25 microns of the tissue surface. It is suggested that important functions of the numerous venules seen in synovium may include the provision of a source of fresh monocytes to replace surface macrophages and provision of nutrients for the surface layer of cells as a whole, and that the density of the vascular net may reflect angiogenic signals from this cell layer.