Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical Evaluation and Comparison of Parental Satisfaction between Anterior Strip Crown and Conventional Composite Restoration: A Randomized Controlled Trial.

Mymensingh medical journal : MMJ·2025

Same author

Efficacy of repetitive transcranial magnetic stimulation as an adjunctive treatment in resistant obsessive-compulsive disorder: A randomized controlled trial.

Industrial psychiatry journal·2025

Same author

Statistical complexity as indicator of the classical-quantum crossover.

Chaos (Woodbury, N.Y.)·2025

Same author

Insights into the Chemical Durability and Structure of ZnO-Incorporated Sodium Borosilicate Glasses from Solid-State NMR.

The journal of physical chemistry. B·2025

Same author

An impactful prospective study on pulmonary tuberculosis in geriatric populations besides its clinical outcomes and implications in the Indian subcontinent.

European review for medical and pharmacological sciences·2024

Same author

Review of standard paediatric neuroradiology MRI protocols from 12 UK tertiary paediatric hospitals: is there much variation between centres?

Clinical radiology·2023

Search research articles

Related Experiment Video

Updated: Apr 5, 2026

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

Impaired ILK Function Is Associated with Deficits in Hippocampal Based Memory and Synaptic Plasticity in a FASD Rat

D Bhattacharya¹, E P Dunaway², S Bhattacharya¹

¹Department of Drug, Discovery and Development, Auburn University, Auburn, Alabama, United States of America.

|August 26, 2015

Summary

Prenatal alcohol exposure impairs memory and synaptic plasticity in rats by disrupting the Integrin Linked Kinase (ILK) signaling pathway, affecting Glycogen Synthase Kinase 3β (GSK3β) and GluR2 AMPA receptors.

More Related Videos

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD

Published on: February 2, 2017

Related Experiment Videos

Last Updated: Apr 5, 2026

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD

Published on: February 2, 2017

Area of Science:

Neuroscience
Developmental Biology
Pharmacology

Background:

Fetal Alcohol Spectrum Disorder (FASD) causes cognitive deficits due to prenatal alcohol exposure.
Current treatments for FASD are ineffective due to incomplete understanding of its cellular and molecular mechanisms.
Alcohol impacts integrins and growth factor signaling, with Integrin Linked Kinase (ILK) being a key effector.

Purpose of the Study:

To investigate the role of the ILK signaling pathway in cognitive deficits associated with FASD.
To determine if ILK pathway impairments contribute to memory and synaptic plasticity deficits in alcohol-exposed offspring.
To examine the relationship between ILK, GSK3β, and glutamate receptor expression in FASD.

Main Methods:

Pregnant Sprague Dawley rats were exposed to alcohol or a sucrose control throughout gestation.
Cognitive function was assessed using contextual fear conditioning in 32-33-day-old pups.
Synaptic plasticity (LTP) and hippocampal ILK signaling, including GSK3β phosphorylation and GluR2/PSD95 interactions, were evaluated.

Main Results:

Alcohol-exposed pups exhibited impaired contextual fear conditioning and reduced long-term potentiation (LTP).
Hippocampal ILK activity and GSK3β phosphorylation were significantly decreased in alcohol-exposed pups.
Increased synaptic GluR2 AMPA receptor expression was observed, with a decreased interaction between ILK and GluR2.

Conclusions:

The ILK signaling pathway is implicated in memory and synaptic plasticity impairments observed in FASD.
These impairments are linked to reduced GSK3β regulation and altered synaptic stabilization of GluR2 AMPA receptors.
Targeting the ILK pathway may offer potential therapeutic strategies for FASD-related cognitive deficits.