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Asymptomatic children might transmit human parechovirus type 3 to neonates and young infants

Yuta Aizawa1, Takayuki Yamanaka2, Kanako Watanabe3

  • 1Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|August 26, 2015
PubMed

Insights

Asymptomatic children in households can transmit human parechovirus type 3 (HPeV3) to infants. This study identified genetically identical HPeV3 in infected infants and their asymptomatic siblings, suggesting children are a key source of HPeV3 infection.

Area of Science:

  • Virology
  • Epidemiology
  • Pediatrics

Background:

  • Human parechovirus type 3 (HPeV3) causes epidemics and severe illness in neonates and infants globally.
  • The primary source of HPeV3 infection remains largely unknown.

Purpose of the Study:

  • To identify the source of HPeV3 transmission within families.
  • To investigate the role of asymptomatic children in the spread of HPeV3.

Main Methods:

  • Analysis of clinical data from 43 infants with HPeV3 disease during a 2014 epidemic in Japan.
  • PCR testing of stool samples from symptomatic and asymptomatic siblings/cousins of infected infants.
  • Sequencing of P1 and 3D(pol) regions of HPeV to confirm transmission.

Main Results:

  • Family contact was confirmed in 51% of HPeV3 cases.
  • Siblings were the most common symptomatic family contacts (67%).
  • Genetically identical HPeV3 strains were found in infected infants and their asymptomatic siblings/cousins.

Conclusions:

  • Asymptomatic children in households serve as a significant source of HPeV3 infection.
  • This finding is crucial for understanding and preventing HPeV3 transmission in vulnerable neonates and infants.
Abstract

Keywords:
Asymptomatic siblingsEpidemicFecesHuman parechovirus type 3NeonatesTransmission

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