Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying the Presence and Characteristics of Mid-Myocardial and Epicardial Fibrosis From Intracardiac Electrograms in Patients Undergoing Ventricular Arrhythmia Ablation Using a Transformer-Based Self-Supervised Classifier.

Circulation. Arrhythmia and electrophysiology·2026
Same author

Antithetic Sampling Enhanced Probabilistic Diffusion for Denoising Cardiac Time Series.

IEEE journal of biomedical and health informatics·2026
Same author

Electrophysiologically-informed digital twins for atrial fibrillation.

Medical image analysis·2026
Same author

Detecting and Mitigating Bias for Inclusive and Trustworthy Clinical Research: A Scientific Statement From the American Heart Association.

Circulation. Genomic and precision medicine·2026
Same author

Ultrasound-guided parasternal tunneling during intermuscular subcutaneous implantable cardioverter-defibrillator implantation is associated with lower shock impedance and more favorable implant geometry.

Heart rhythm·2026
Same author

Editorial commentary: Pulsed field versus thermal ablation for atrial fibrillation.

Trends in cardiovascular medicine·2026

Related Experiment Video

Updated: Apr 5, 2026

Robotic Ablation of Atrial Fibrillation
11:21

Robotic Ablation of Atrial Fibrillation

Published on: May 29, 2015

20.4K

Ablating Atrial Fibrillation: Customizing Lesion Sets Guided by Rotor Mapping.

Junaid A B Zaman1, Sanjiv M Narayan2

  • 1Stanford University, Palo Alto, California ; Imperial College London, London, United Kingdom.

Methodist Debakey Cardiovascular Journal
|August 26, 2015
PubMed
Summary

Identifying rotors and focal sources in atrial fibrillation (AF) offers a new approach to ablation. Targeting these non-pulmonary vein sites improves long-term outcomes for persistent AF patients.

Keywords:
FIRM mappingatrial fibrillationcomplex fractionated atrial electrogramsfocal impulse and rotor modulation mappingrotor mappingsurgical ablation

More Related Videos

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation
09:17

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation

Published on: July 29, 2011

15.3K
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

11.1K

Related Experiment Videos

Last Updated: Apr 5, 2026

Robotic Ablation of Atrial Fibrillation
11:21

Robotic Ablation of Atrial Fibrillation

Published on: May 29, 2015

20.4K
High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation
09:17

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation

Published on: July 29, 2011

15.3K
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

11.1K

Area of Science:

  • Electrophysiology
  • Cardiac Arrhythmia Management
  • Minimally Invasive Cardiac Procedures

Background:

  • Atrial fibrillation (AF) ablation is increasingly used but has suboptimal outcomes, especially for persistent forms.
  • While pulmonary vein (PV) isolation is standard, AF recurrence often involves non-PV drivers.
  • New mapping technologies reveal persistent rotor and focal sources sustaining AF.

Purpose of the Study:

  • To review the mechanistic basis for targeting rotors and focal sources in AF.
  • To discuss technical advancements in wide-area mapping for AF driver identification.
  • To explore the clinical implementation of rotor mapping for personalized ablation strategies.

Main Methods:

  • Review of recent developments in wide-area mapping and signal processing for AF.
  • Analysis of multicenter studies demonstrating the efficacy of rotor elimination.
  • Discussion of spatio-temporal stability and ablation characteristics of identified AF sources.

Main Results:

  • Rotor and focal sources sustaining AF are identified in most patients.
  • Elimination of these drivers improves long-term freedom from AF in multicenter studies.
  • These sources exhibit reproducible locations and are amenable to targeted ablation.

Conclusions:

  • Rotor mapping represents a mechanistic paradigm shift for AF ablation.
  • Personalized lesion sets based on rotor mapping may improve patient outcomes.
  • Further mechanistic studies are needed to refine acute termination and integrate findings with structural imaging and current strategies.