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High Prevalence of Y Chromosome Partial Microdeletions in Overweight Men
Atefeh Biabangard Zak1, Masoud Golalipour1, Gholamreza Hadadchi1
1Department of Biology, School of Basic Sciences, Golestan University, Gorgan, Iran.
Background:
Microdeletions of the Y chromosome are one of the most frequent genetic causes of spermatogenic failure in infertile men. But their role in gaining weight is unclear. The present study investigated the possible association of these partial microdeletions and obesity.
Methods:
In a case-control study, 180 males were selected. The prevalence of microdeletions was assessed using PCR in AZFc area of Y chromosome and statistical analysis was done using the Fisher exact test and Pearson correlation.
Results:
In our study, inverse relationship was observed between body mass index and testosterone level (p-value: 0.005). Fisher exact tests showed that there was a significant association between gr/gr mutation and BMI (p-value: 0.044).
Conclusion:
Our study revealed that Y chromosome microdeletions are more common in obese men. Furthermore, microdeletions such as gr/gr, which were observed in normal men, could cause decreased testosterone level. So, they may contribute to gaining weight.
Insights
Y chromosome microdeletions are more prevalent in obese men and may contribute to weight gain by potentially lowering testosterone levels. This study explored the link between these genetic factors and obesity.
Area of Science:
- Genetics
- Endocrinology
- Reproductive Health
Background:
- Y chromosome microdeletions are a leading genetic cause of male infertility.
- The connection between Y chromosome microdeletions and obesity remains largely unexplored.
Purpose of the Study:
- To investigate the potential association between Y chromosome microdeletions and obesity in males.
- To explore the relationship between specific microdeletions, body mass index, and testosterone levels.
Main Methods:
- A case-control study involving 180 males.
- Polymerase Chain Reaction (PCR) was used to detect microdeletions in the AZFc region of the Y chromosome.
- Statistical analyses included Fisher exact test and Pearson correlation.
Main Results:
- An inverse relationship was found between body mass index (BMI) and testosterone levels (p=0.005).
- A significant association was observed between the gr/gr microdeletion and BMI (p=0.044).
Conclusions:
- Y chromosome microdeletions are more frequently observed in obese men.
- Microdeletions, such as gr/gr, may lead to reduced testosterone levels, potentially contributing to weight gain.
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