[Nephrotic syndrome in Crohn's disease]
H J Henk-Jan Boiten1, Pieter Honkoop, Peter J H Smak Gregoor
1Albert Schweitzer Ziekenhuis, Dordrecht.
Nederlands Tijdschrift Voor Geneeskunde
|August 27, 2015
Summary
Nephrotic syndrome can be caused by medications. A patient with Crohn's disease developed membranous glomerulopathy while on adalimumab, which resolved after stopping the drug.
Area of Science:
- Nephrology
- Immunology
Background:
- Nephrotic syndrome presents a diverse differential diagnosis.
- Systemic conditions and medications, including NSAIDs, can precipitate nephrotic syndrome.
Observation:
- A 33-year-old male with Crohn's disease on adalimumab developed nephrotic syndrome with membranous glomerulopathy.
- Secondary causes of membranous glomerulopathy were excluded.
Findings:
- Treatment with high-dose glucocorticoids and adalimumab discontinuation led to complete remission.
- A likely association between adalimumab use and the development of membranous glomerulopathy was identified.
Implications:
- This case highlights the importance of considering medication side effects in nephrotic syndrome.
- Thorough exclusion of primary and secondary causes, including drug-induced cases, is crucial for managing membranous glomerulopathy.
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