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Attenuating Diabetes: What Really Works?

Navpreet Kaur, Lalit Kishore, Randhir Singh1

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Herbal medicine offers a cost-effective and safe alternative for managing diabetes mellitus, a condition affecting glucose homeostasis. This review examines preclinical and clinical data on medicinal herbs and their mechanisms for diabetes treatment.

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Area of Science:

  • Pharmacology and Herbal Medicine
  • Endocrinology and Metabolic Diseases

Background:

  • Diabetes mellitus is a chronic condition marked by impaired glucose homeostasis and altered lipid and protein metabolism.
  • Current allopathic treatments for diabetes face challenges due to side effects and high costs, necessitating exploration of alternative therapies.
  • Medicinal herbs have a long history of use in traditional medicine for managing diabetes and are a rich source of potential therapeutic agents.

Purpose of the Study:

  • To review and synthesize current preclinical and clinical research on medicinal herbs used for diabetes management.
  • To evaluate the efficacy and safety of herbal remedies in controlling diabetes mellitus.
  • To explore the pharmacological mechanisms of action of these medicinal herbs in the context of diabetes.

Main Methods:

  • Comprehensive literature search of preclinical (in vitro, animal studies) and clinical (human trials) data.
  • Inclusion of studies focusing on medicinal plants with reported anti-diabetic properties.
  • Analysis of reported mechanisms of action, including effects on glucose metabolism, insulin sensitivity, and antioxidant pathways.

Main Results:

  • A significant number of medicinal herbs demonstrate promising anti-diabetic effects in preclinical and clinical studies.
  • Herbal interventions show potential in improving glucose control, enhancing insulin sensitivity, and reducing oxidative stress.
  • Plant-derived compounds are increasingly recognized for their therapeutic value, contributing to modern pharmacopoeia.

Conclusions:

  • Medicinal herbs represent a viable, cost-effective, and safe therapeutic option for the management of diabetes mellitus.
  • Further rigorous clinical investigation is warranted to establish the efficacy and optimal use of specific herbal treatments.
  • Herbal medicine holds significant potential for complementing conventional diabetes pharmacotherapy.