Related Experiment Video

Updated: Apr 5, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

2.3K

Cerebral alterations of type 2 diabetes mellitus on MRI: A pilot study

Bo Peng1, Zhiye Chen2, Lin Ma2

  • 1Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China; University of Chinese Academy of Sciences, Beijing 100049, China; Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China.

Neuroscience Letters
|August 27, 2015
PubMed

Insights

Type 2 diabetes mellitus (T2DM) is linked to brain structure changes. This study found reduced gray matter volume, cortical thickness, and surface area in T2DM patients, aiding early diagnosis.

Area of Science:

  • Neuroimaging
  • Endocrinology
  • Neurology

Background:

  • Type 2 diabetes mellitus (T2DM) is a growing global health concern.
  • Emerging evidence suggests T2DM may affect brain structure and function.
  • Understanding these neural alterations is crucial for early detection and management.

Purpose of the Study:

  • To investigate brain structural changes in T2DM patients.
  • To quantify differences in gray matter volume, cortical thickness, and surface area.
  • To identify specific brain regions affected by T2DM.

Main Methods:

  • Acquisition of high-resolution T1-weighted MRI scans from 18 T2DM patients and 17 healthy controls.
  • Processing of MRI data using a novel BrainLab toolbox.
  • Analysis of regional differences in gray matter volume, cortical thickness, and surface area.

Main Results:

  • T2DM patients exhibited significant reductions in gray matter volume in the left and right caudate nuclei.
  • Cortical thickness was reduced in the temporal, parietal, and occipital lobes.
  • Surface area reductions were primarily observed in the frontal lobe.

Conclusions:

  • T2DM is associated with significant structural brain alterations in specific regions.
  • These findings highlight potential neuroimaging biomarkers for T2DM.
  • This research contributes to understanding the neural underpinnings of T2DM and its early diagnosis.
Keywords:
Brain MRICortical thicknessGray matter volumeSurface areaType 2 diabetes mellitus

More Related Videos

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images08:39

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Published on: November 20, 2015

14.1K
Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

12.7K

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.6K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
6.1K
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
10.4K