Comparison of the 2 Most Popular Deconvolution Techniques for the Detection of Penumbral Flow in Acute Stroke
Olivier Zaro-Weber1, Michelle Livne2, Steve Z Martin2
1From the Max-Planck-Institute for Metabolism Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.); Center for Stroke Research Berlin (CSB) (M.L., S.Z.M., F.C.v.S.-H., P.B., J.S., V.I.M.) and Department of Neurology (J.S., V.I.M.), Charité-Universitätsmedizin, Berlin, Germany; Fraunhofer MEVIS, Bremen, Germany (F.C.v.S.-H.); Department of Radiology, Ludmillenstift, Meppen, Germany (W.M.-H.); and Max-Planck-Institute for Neurological Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.). vince_istvan.madai@charite.de zaroweber@nf.mpg.de.
Background And Purpose:
Dynamic susceptibility-weighted contrast-enhanced (DSC) magnetic resonance imaging (MRI) is used to identify the tissue-at-risk in acute stroke, but the choice of optimal DSC postprocessing in the clinical setting remains a matter of debate. Using 15O-water positron emission tomography (PET), we validated the performance of 2 common deconvolution methods for DSC-MRI.
Methods:
In (sub)acute stroke patients with consecutive MRI and PET imaging, DSC maps were calculated applying 2 deconvolution methods, standard and block-circulant single value decomposition. We used 2 standardized analysis methods, a region of interest-based and a voxel-based analysis, where PET cerebral blood flow masks of <20 mL/100 g per minute (penumbral flow) and gray matter masks were overlaid on DSC parameter maps. For both methods, receiver operating characteristic curve analysis was performed to identify the accuracy of each DSC-MR map for the detection of PET penumbral flow.
Results:
In 18 data sets (median time after stroke onset: 18 hours; median time PET to MRI: 101 minutes), block-circulant single value decomposition showed significantly better performance to detect PET penumbral flow only for mean transit time maps. Time-to-maximum (Tmax) had the highest performance independent of the deconvolution method.
Conclusions:
Block-circulant single value decomposition seems only significantly beneficial for mean transit time maps in (sub)acute stroke. Tmax is likely the most stable deconvolved parameter for the detection of tissue-at-risk using DSC-MRI.
