Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 5, 2026

Biomechanical Testing of Murine Tendons
10:09

Biomechanical Testing of Murine Tendons

Published on: October 15, 2019

14.3K

PAPP-A affects tendon structure and mechanical properties.

Tai-Hua Yang1, Andrew R Thoreson1, Kai-Nan An1

  • 1Biomechanics Laboratory and Tendon and Soft Tissue Biology Laboratory, Division of Orthopedic Research, Mayo Clinic, Rochester, MN 55905, USA.

Journal of Structural Biology
|August 27, 2015
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial Intelligence Models for Classifying Wrist Ligament Injuries Using Synthetically-Generated Joint Proximity Maps from Finite Element Models.

bioRxiv : the preprint server for biology·2026
Same author

Percutaneous spinal stimulation to enhance gait and alleviate functional impairments in multiple sclerosis: A pilot study.

Multiple sclerosis journal - experimental, translational and clinical·2026
Same author

AI-assisted six-dimensional CT imaging for joint instability assessment.

Proceedings of SPIE--the International Society for Optical Engineering·2026
Same author

Therapy-specific motoneuron activation with epidural and dorsal root ganglion stimulation in spinal cord injury.

Journal of neurophysiology·2026
Same author

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome.

Science advances·2026
Same author

Finite Element Modeling of the Scaphoid Shift Maneuver: Implications for Scapholunate Ligament injuries.

bioRxiv : the preprint server for biology·2026

Pregnancy-associated plasma protein-A (PAPP-A) influences tendon structure and mechanical properties. PAPP-A knockout mice showed impaired tendon development, while overexpression enhanced it.

Area of Science:

  • Biochemistry
  • Musculoskeletal Biology
  • Connective Tissue Research

Background:

  • Pregnancy-associated plasma protein-A (PAPP-A) is known to enhance insulin-like growth factor (IGF) signaling by degrading IGF-binding proteins.
  • This action promotes cell proliferation and differentiation in various tissues.

Purpose of the Study:

  • To investigate the specific role of PAPP-A in modulating tendon structure and mechanical characteristics.
  • To understand how PAPP-A expression levels impact tendon development and function.

Main Methods:

  • Utilized PAPP-A knockout (KO), skeletal-specific overexpression transgenic (Tg), and wild-type (WT) mouse tail models (n=10 per group).
  • Assessed morphological parameters including cross-sectional area (CSA) of tail, bone, muscle, and tendon, alongside fascicle diameter.
Keywords:
Fascicle mechanical propertyInterfascicular structureKnockout mouseOverexpression mousePregnancy-associated plasma protein-ATendon

More Related Videos

Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation
07:50

Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation

Published on: January 27, 2023

3.9K
Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

1.9K

Related Experiment Videos

Last Updated: Apr 5, 2026

Biomechanical Testing of Murine Tendons
10:09

Biomechanical Testing of Murine Tendons

Published on: October 15, 2019

14.3K
Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation
07:50

Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation

Published on: January 27, 2023

3.9K
Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

1.9K
  • Performed fascicle pullout tests and uniaxial tension tests to evaluate stiffness, strength, modulus, hysteresis, and stress relaxation.

    • Main Results:

    • KO mice exhibited reduced tail and tendon CSA, smaller fascicle diameter, decreased stiffness, and increased hysteresis compared to WT and Tg mice.
    • Tg mice displayed larger fascicle diameter, increased tendon CSA, enhanced interfascicular strength and stiffness, and altered modulus compared to WT and KO mice.
    • Tg mice showed larger total tail CSA and smaller hysteresis than KO mice, and larger normalized tendon CSA than WT mice.

    Conclusions:

    • PAPP-A significantly influences tendon fascicle structure.
    • Modulation of PAPP-A levels directly impacts the overall tendon phenotype, affecting its mechanical properties and structural integrity.