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Acinetobacter lwoffii an emerging pathogen in neonatal ICU
Seema Mittal1, Madhu Sharma, Aparna Yadav
1Department of Microbiology, Pt. B.D.S. PGIMS Rohtak-124001, Haryana, India. dr.sima2010@rediffmail.com.
Infectious Disorders Drug Targets
|August 27, 2015
Summary
Multi-drug resistant Acinetobacter lwoffii is an increasing threat in neonatal sepsis. Judicious antibiotic use in neonatal intensive care units (NICUs) is crucial for controlling infections and improving outcomes.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Neonatology
Background:
- Acinetobacter species are common environmental bacteria and a significant cause of nosocomial infections, particularly in immunocompromised individuals.
- Multi-drug resistant Acinetobacter lwoffii is an emerging pathogen contributing to neonatal sepsis.
Purpose of the Study:
- To evaluate the clinical characteristics and antibiotic susceptibility profile of Acinetobacter lwoffii isolates.
- To understand the prevalence and resistance patterns of Acinetobacter lwoffii in a neonatal intensive care unit (NICU) setting.
Main Methods:
- Blood samples from neonates admitted to the NICU over a one-year period (January-December 2012) were analyzed for Acinetobacter infections.
- Isolate identification and antibiotic susceptibility testing were performed using both conventional and automated methods.
Main Results:
- Out of 13,133 blood cultures, 90 (6.3%) yielded Acinetobacter species.
- Acinetobacter lwoffii accounted for 31.11% of Acinetobacter isolates, while Acinetobacter baumannii calcaetius complex comprised 68.9%.
- Acinetobacter lwoffii isolates showed the highest sensitivity to imipenem (57%), followed by cotrimoxazole (32%) and ciprofloxacin (21%).
Conclusions:
- Multi-drug resistant Acinetobacter lwoffii infections are rising, especially in premature and low-birth-weight neonates.
- Prudent and timely antibiotic administration in NICUs is essential for managing multi-drug resistant Acinetobacter infections and enhancing clinical outcomes.
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