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Acinetobacter lwoffii an emerging pathogen in neonatal ICU
Seema Mittal1, Madhu Sharma, Aparna Yadav
1Department of Microbiology, Pt. B.D.S. PGIMS Rohtak-124001, Haryana, India. dr.sima2010@rediffmail.com.
Background:
Acinetobacter species are ubiquitous in the environment and are important causative agent for nososcomial infection especially in immunocompromised patients. Multi drug resistant Acinetobacter lwoffii are emerging as a pathogen in neoanatal sepsis.
Aims And Objective:
This study was aimed to evaluate the clinical and antibiotic profile of Acinetobacter lwoffii.
Material And Methods:
This study was done on blood samples from neonates admitted to neonatal intensive care unit during a period of one year from January to December 2012, who developed Acinetobacter infection. The diagnosis of isolates and antibiotic susceptibility testing was done by both conventional as well as by automated system.
Results:
Out of total 13,133 blood samples received for culture, 1418(10.8%) were from NICU. Ninety (6.3%) isolates were found to be positive for the growth of Acinetobacter species. Of these isolates 31.11% were found to be Acinetobacter lwoffii, 68.9% were Acinetobacter baumannii calcaetius complex. Acinetobacter lwoffii isolates were most commonly sensitive to imepenem 16(57%), cotrimoxazole 9(32%), ciprofloxacin 6(21%) followed by amoxyclavulanic acid 2(7%) and cefuroxime 1(3.5%).
Conclusion:
Multi drug resistant Acinetobacter lwoffii infection is increasing particularly in premature and very low-birth weight neonates. Judicious and timely antibiotic use in NICUs are one of the important key in controlling multi-drug resistant Acinetobacter infection and improving clinical outcome.
Insights
Multi-drug resistant Acinetobacter lwoffii is an increasing threat in neonatal sepsis. Judicious antibiotic use in neonatal intensive care units (NICUs) is crucial for controlling infections and improving outcomes.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Neonatology
Background:
- Acinetobacter species are common environmental bacteria and a significant cause of nosocomial infections, particularly in immunocompromised individuals.
- Multi-drug resistant Acinetobacter lwoffii is an emerging pathogen contributing to neonatal sepsis.
Purpose of the Study:
- To evaluate the clinical characteristics and antibiotic susceptibility profile of Acinetobacter lwoffii isolates.
- To understand the prevalence and resistance patterns of Acinetobacter lwoffii in a neonatal intensive care unit (NICU) setting.
Main Methods:
- Blood samples from neonates admitted to the NICU over a one-year period (January-December 2012) were analyzed for Acinetobacter infections.
- Isolate identification and antibiotic susceptibility testing were performed using both conventional and automated methods.
Main Results:
- Out of 13,133 blood cultures, 90 (6.3%) yielded Acinetobacter species.
- Acinetobacter lwoffii accounted for 31.11% of Acinetobacter isolates, while Acinetobacter baumannii calcaetius complex comprised 68.9%.
- Acinetobacter lwoffii isolates showed the highest sensitivity to imipenem (57%), followed by cotrimoxazole (32%) and ciprofloxacin (21%).
Conclusions:
- Multi-drug resistant Acinetobacter lwoffii infections are rising, especially in premature and low-birth-weight neonates.
- Prudent and timely antibiotic administration in NICUs is essential for managing multi-drug resistant Acinetobacter infections and enhancing clinical outcomes.
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