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Updated: Apr 5, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
Genome-wide association study of prostate cancer-specific survival
Robert Szulkin1, Robert Karlsson2, Thomas Whitington2
1Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. Academic Primary Healthcare Center, Stockholm County Council, Karolinska Institute, Stockholm, Sweden. robert.szulkin@ki.se.
Background:
Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.
Methods:
We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).
Results:
We observed no significant association between genetic variants and prostate cancer survival.
Conclusions:
Common genetic variants with large impact on prostate cancer survival were not observed in this study.
Impact:
Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.
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