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Regulatory Roles of Non-Coding RNAs in Colorectal Cancer

Jun Wang1, Yong-Xi Song2, Bin Ma3

  • 1Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. wjj100@163.com.

International Journal of Molecular Sciences
|August 27, 2015
PubMed

Insights

Non-coding RNAs (ncRNAs) play roles in biological processes and cancer. This review examines ncRNA regulation in colorectal cancer (CRC), highlighting their potential as biomarkers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Non-coding RNAs (ncRNAs) are increasingly recognized for their roles in biological functions.
  • Aberrant ncRNA expression is linked to various diseases, notably cancer.

Purpose of the Study:

  • To comprehensively review the aberrant regulation of ncRNAs in colorectal cancer (CRC).
  • To summarize current findings on diverse ncRNA types in CRC.
  • To explore the potential of ncRNAs as biomarkers and therapeutic targets for CRC.

Main Methods:

  • Literature review of studies on ncRNA regulation in colorectal cancer.
  • Categorization and summary of findings for different ncRNA classes (long ncRNAs, microRNAs, siRNAs, snoRNAs, snRNAs, piRNAs, circRNAs).

Main Results:

  • ncRNAs, including long ncRNAs, microRNAs, and circular RNAs, are frequently dysregulated in CRC.
  • Specific ncRNAs show potential as diagnostic or prognostic biomarkers for CRC.
  • ncRNAs represent promising targets for novel CRC therapies.

Conclusions:

  • ncRNAs are critically involved in the pathogenesis of colorectal cancer.
  • Further research into ncRNA mechanisms in CRC may yield novel therapeutic strategies.
  • ncRNAs hold significant promise as future biomarkers and therapeutic agents for CRC.
Keywords:
biomarkerscolorectal cancerdysregulationnon-coding RNAstargets

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