Propofol-induced rhabdomyolysis: a case report
International Journal of Clinical Pharmacology and Therapeutics
|August 27, 2015
Summary
Propofol anesthesia can cause severe muscle breakdown (rhabdomyolysis), even with standard doses. This case highlights propofol-induced rhabdomyolysis, distinct from malignant hyperthermia, emphasizing careful administration.
Area of Science:
- Anesthesiology
- Toxicology
- Pathology
Background:
- Propofol is a widely used intravenous anesthetic agent.
- Rhabdomyolysis is a serious medical condition involving muscle breakdown.
- Propofol infusion syndrome (PRIS) is a rare but severe complication associated with propofol use.
Observation:
- A 54-year-old female developed ventricular fibrillation shortly after propofol induction for hysterectomy.
- Despite intensive care, the patient did not recover.
- Autopsy revealed widespread myolysis affecting skeletal and cardiac muscle.
Findings:
- The patient exhibited robust evidence of rhabdomyolysis.
- Clinical features were consistent with propofol-induced rhabdomyolysis, not malignant hyperthermia.
- Rhabdomyolysis was attributed to propofol, as it was the only potential causative agent.
Implications:
- Propofol-induced rhabdomyolysis may present differently than malignant hyperthermia.
- Standard propofol induction doses can potentially trigger rhabdomyolysis, similar to PRIS in children.
- Clinicians should exercise caution when administering propofol due to the risk of rhabdomyolysis.
