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Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
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A Short Introduction to Arterial Spin Labeling and its Application to Flow Territory Mapping
T Lindner1, M Helle2, O Jansen3
1Clinic for Radiology and Neuroradiology, UKSH Campus Kiel, 24105, Kiel, Arnold-Heller-Straße 3, Germany. Thomas.Lindner@uksh.de.
Clinical Neuroradiology
|August 27, 2015
Summary
Arterial spin labeling (ASL) offers a non-invasive method to quantify cerebral blood flow and map brain perfusion territories. This technique provides an alternative to contrast-enhanced imaging for assessing cerebrovascular diseases.
Area of Science:
- Neuroimaging
- Medical Physics
- Radiology
Background:
- Arterial spin labeling (ASL) is an emerging non-invasive neuroimaging technique.
- It assesses brain perfusion by manipulating arterial blood water magnetization.
- ASL offers an alternative to contrast-enhanced imaging methods.
Purpose of the Study:
- To provide an overview of basic ASL methodology.
- To explain ASL approaches for imaging individual perfusion territories.
- To present ASL utilization in cerebrovascular diseases for clinical applications.
Main Methods:
- Non-invasive manipulation of arterial blood water spin magnetization.
- Absolute quantification of cerebral blood flow.
- Flow territory mapping for intracerebral blood flow configuration.
Main Results:
- ASL enables absolute quantification of cerebral blood flow.
- ASL can be used for individual perfusion territory mapping.
- ASL demonstrates potential in assessing various cerebrovascular diseases.
Conclusions:
- ASL is a valuable non-invasive tool for assessing brain perfusion and mapping flow territories.
- Its application in cerebrovascular diseases shows promise for clinical routine.
- ASL provides an alternative to contrast-enhanced imaging for perfusion assessment.
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